|
KMID : 0879420010030010029
|
|
Journal of the Implant Research
2001 Volume.3 No. 1 p.29 ~ p.46
|
|
|
Experimental study on the influence of Platelet-Rich Plasma(PRP) with bovine bone graft I the calvaria of rabbits)
|
|
|
|
|
Abstract
|
|
|
There are so many cases which need grafts of bone defect as the reconstruction of post-tumor
resection surgery site or trauma site, surgical management of alveolar cleft and oronasal fistula, bone
grafts associated with osseointegrated implants and maxillary sinus lifting procedure. R
Among the method of bone defect reconstruction, that which uses the fresh autogenous bone has Fi!
disadvantages that it gives also another trauma on the donor site and volume is reduced after the
operation and it has limit of quantity. Another method using the commercial allogenic bone and Fi,
composite Wne like the Hydroxyapatite and Tricalcium phosphate has disadvantages that it takes poor
tissue responses and its material works only as the passive scaffold. Fi
To gain the functional and much alveolar bone, Research is being carried recently that developing and
purifying the various growth. factor, applying the.results of research to clinical situation. The materials Fi
promoting the bone formation are Bone Morphogenetic Protein(BMP), Platelet-Derived Growth
Factor(PDGF), Transforming Growth Factor-beta(TGF- R). It is reported that Platelet-Rich
Fi
Plasma(PRP) has PDGF, TGF- R and the ability of promoting the bone formation.
In this study, I compared the defect that have been healed naturally without any bone grafts as the
control site, the other defect have been augmented only with bovine bone grafts, with another defect F
have been augmented with bovine bone grafts and Platelet-Rich Plasma simultaneously. I wanted to see F
whether much better results of bone formation on using the PRP have been gained, through the method
of histologic evaluation. The results was gained as follows on the light microscopic examination.
1. The defect have been augmented with bovine bone grafts and PRP simultaneously showed the higher bone density and much bone formation than that have been augmented only with bovine bone grafts, especially on the eighth week´s histologic examination.
2. Comparing the histologic specimen of the defects by the time elapse, Bone grafts with PRP simultaneously had the fastest bone growth rate among the three defects above.
3. The defect that have been healed naturally without any bone grafts had much fibrous tissue and less new bone formation.
It seems that using the bone graft and PRY simultaneously on the bone defect gains the better bone healing as the above results.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|
|